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can a negative anti-ccp change in to a positive? Options
emily
#1 Posted : Monday, August 06, 2012 11:41:52 AM Quote
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Joined: 12/3/2009
Posts: 89
Hello,
am wondering if anyone can help answer my concerns for a dear friend.

He has been experiencing wide spread pain in majority of joints over a period of several months. Joints are stiff throughout the day and feels tired continously. He is also breathless and generally feels unwell.

He has had all the relevant tests for RA as the consultant was sure this is what it is aS his feet have deformaties with toes pointing wrong way etc...

All bloods show no inflammation! My questions is that can the anti-ccp test ever turn in to a positive, or if its a negative then that is a definate that it is not RA? Do you know of anyone where the test has changed When re-tested at a later date?

Many thanks
emilyxxx.
smith-j
#2 Posted : Monday, August 06, 2012 8:19:45 PM Quote
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Joined: 12/3/2009
Posts: 714
Emily

From my own experience yes you can have RA without your bloods showing inflammation.

I was diagnosed three years ago with RA but my Consultant thinks I have had it all my life. I kept on having "episodes" over the years where my joints would sieze up and I would be very unwell for weeks at a time but all blood tests returned normal and it was put down to a "virus". I now have very bad joint damage.

I believe you can be sero-negative with RA and I know there are members of this site who are, so perhaps they can give you more information. My Consultant did say he takes very little notice of blood tests and listens to the patient and the symptoms they present with.

I myself would suggest that your friend gets a second opinion and keeps on at his doctors to find an answer.

Take care

Jackie
x
benmaise
#3 Posted : Monday, August 06, 2012 9:37:30 PM Quote
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Hi I am sero negative aswell. I had a few blood test and the doc said it wasn't positive.
As soon as i saw the Rheumatologist , he looked at my joints asked me some questions and said i had it .
Looks like your friends has R A unfortunately.
Kathleen Mc
zena_mary
#4 Posted : Tuesday, August 07, 2012 12:12:39 PM Quote
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Joined: 1/21/2012
Posts: 388
Location: Powys
Yes I was originally diagnosed as sero-negative but somewhere along the line became possitive.
I only found out that it had changed when I was asked to go onto rtx treatment and had read that it is not likely to be a success for patients who are sero-neg. I questioned having the ra factor and was told that yes, I did now have it all being at a low count.
My sister is struggling to get a possitive diagnosis after 2 yrs or so. She does not show inflamation or ra factor poss. Her reumatologist constantly tells her that he cannot diagnose ra without inflamation, but keeps reviewing her every 6mnths.
Anyway good luck with finding a way forward for your friend. Zena.
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